Facultatea de Fizică
Universitatea "Al.I.Cuza" Iaşi
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| Titlu: Structural characterization of soft gelatin nanofibers |
| Autori: Goldemberg Marcel Raul1, Valentin Nica1, Gheorghiţă Zbancioc2,Ionel Mangalagiu2, Vasile Ţura1 |
| Afiliere: 1Faculty of Physics, 2Faculty of Chemistry, „Al. I. Cuza” University,Iaşi |
| Abstract: Gelatin and collagen are natural biopolymers widely
used in medical and pharmaceutical applications. In the
last years, the use of gelatin nanofibers as wound
dressings and drug delivery carriers had found many
applications in biomedicine [1, 2]. Gelatin based wound
dressings and drug delivery systems have many
advantages as compared with traditional materials, such
as improved therapeutic effects, reduced toxicity and
convenience [3].
Due to their strong polarity, gelatin molecular
chains are connected through strong hydrogen bonds and
form 3D macromolecular networks (double or triple
helix) with reduced mobility. When high-polarity
solvents are acting on gelatin, the links between chains
are broken and the biopolymer structure changes from
helix to random-coil. Moreover, gelatin undergoes
reversible helix-coil transformations, depending on the
solvents used. The addition of a crosslinking agent to a
gelatin solution may promote or hinder the helix
recovery, depending on the relative rates of crosslinking
and helix formation [4]. |
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