Facultatea de Fizică
Universitatea "Al.I.Cuza" Iaşi
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| Titlu: DNA damages induced by ionizing radiations: a Monte Carlo investigation |
| Autori: Andreea Verdes 1 , Catalin Borcia 2 , Dan Mihailescu 2 |
| Afiliere: 1 Institutul de Sănătate Publică, Laboratorul de Igiena Radiaţiilor, 700465 Iaşi
2 Universitatea „Al. I. Cuza“, Facultatea de Fizică, 700506 Iaşi |
| Abstract: The purpose of this work was to theoretically investigate the clustering process within the deoxyribonucleic acid
(DNA) using a fast Monte Carlo code for damages simulation, MCDS, released by by R. D. Stuart and colab. from Purdue
University (USA). MCDS algorithm provides a very fast quasiphenomenological
method to interpolate damage yields from
computationally expensive, but more detailed, trackstructure
simulations. We have calculated the overall yield of SSBs,
DSBs and sites of multiple BDs as well as the DNA damage spectra for electrons (low LET), protons and alpha particles
(higher LET particles) in the energy range 1 – 5.3 MeV. As expected, DNA lesions become more complex as LET increases.
Such theoretical studies are useful for biophysical modelling, guiding the present and future experimental efforts in
radiobiology. |
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